Title: Quinethazone
CAS Registry Number: 73-49-4
CAS Name: 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide
Additional Names: 7-chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone; 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline
Manufacturers' Codes: CL-36010
Trademarks: Hydromox (Lederle); Aquamox (Lederle)
Molecular Formula: C10H12ClN3O3S
Molecular Weight: 289.74
Percent Composition: C 41.45%, H 4.17%, Cl 12.24%, N 14.50%, O 16.57%, S 11.07%
Literature References: Prepn: Cohen et al., J. Am. Chem. Soc. 82, 2731 (1960); Cohen, Vaughan, Jr., US 2976289 (1961 to Am. Cyanamid).
Properties: Fibrous crystals from 50% acetone, mp 250-252°. Sol in acetone, alcohol.
Melting point: mp 250-252°
Therap-Cat: Diuretic, antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs. |