Title: Polihexanide
CAS Registry Number: 32289-58-0; 28757-47-3 (base)
CAS Name: Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride
Additional Names: polyaminopropylbiguanide; polyhexamethylene biguanide hydrochloride; polyhexanide; PHMB
Trademarks: Cosmocil CQ (Arch); Lavasept (Fresenius); Vantocil (Arch)
Line Formula: (C8H17N5)n.xHCl
Literature References: Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes. Prepn: F. L. Rose, G. Swain, US 2643232 (1953 to ICI). Antibacterial action: A. Davies et al., J. Appl. Bacteriol. 31, 448 (1968). Synthesis and characterization of solution behavior: G. C. East et al., Polymer 38, 3973 (1997). Interactions with phospholipid membranes: P. Broxton et al., J. Appl. Bacteriol. 57, 115 (1984); T. Ikeda et al., Bull. Chem. Soc. Jpn. 58, 705 (1985). Mechanism of action study: W. Khunkitti et al., J. Appl. Microbiol. 82, 107 (1997). Titrimetric determn of biguanide groups: T. Hattori et al., Anal. Sci. 19, 1525 (2003). Clinical evaluation of mouthrinse formulations on bacterial count and plaque growth: M. Rosin et al., J. Clin. Periodontol. 28, 1121 (2001); 29, 392 (2002).
Properties: Sol in water.
Use: Biocide in personal hygiene products, contact lens solutions, industrial disinfectants, textiles, and household products; preservative in cosmetics.
Therap-Cat: Antiseptic; disinfectant.
Keywords: Antiseptic/Disinfectant; Guanidines. |