Title: Leucinocaine Mesylate
CAS Registry Number: 135-44-4
CAS Name: 2-(Diethylamino)-4-methyl-1-pentanol 4-aminobenzoate (ester) monomethanesulfonate (salt)
Additional Names: 2-diethylamino-4-methylpentyl p-aminobenzoate methanesulfonate; p-aminobenzoic acid b-diethylaminoisohexyl ester methanesulfonate; p-aminobenzoic acid N,N-diethylleucinol ester methanesulfonate; p-aminobenzoyl-N-1-diethylamino-1-isobutylethanol methanesulfonate; 2-methyl-4-diethylaminopentan-5-ol p-aminobenzoate
Trademarks: Panthesin (Novartis)
Molecular Formula: C18H32N2O5S
Molecular Weight: 388.52
Percent Composition: C 55.65%, H 8.30%, N 7.21%, O 20.59%, S 8.25%
Literature References: Prepn: Lebeau, Janot, Traité de Pharmacie Chimique vol. III (Masson et Cie, Paris, 1955-1956) p 1296. Prepn of hydrochloride: Karrer, US 1555217 and see also DE 464484 (1925, 1928 to Chem. Fabrik Flora). Efficacy and toxicity in animals: R. N. Bieter et al., J. Pharmacol. Exp. Ther. 57, 221 (1936).
Properties: Crystals, mp 171°. Sol in 3 parts water, alcohol. Practically insol in ether, petr ether, ethyl acetate, acetone, benzene. MLD in rabbits (mg/kg): 20 i.v.; 10.8 intraspinally (Bieter).
Melting point: mp 171°
Toxicity data: MLD in rabbits (mg/kg): 20 i.v.; 10.8 intraspinally (Bieter)
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).
Status: This monograph has been retired and is no longer subject to revision or update. |