Title: Hypericum
Additional Names: St. John's wort; hyperici herba
Literature References: Herbaceous, perennial plant, Hypericum perforatum L. (Hypericaceae), widely used in traditional medicine. Habit. Europe, Asia, North Africa; naturalized in the U.S. Constit. Hyperforin, hypericin, q.q.v., pseudohypericin; flavonoids such as hyperin, rutin, quercetin; biapigenins; essential oil; tannins; procyanidins. Medicinal formulations are prepared from the dried flowering tops. Description of botany, constituents and medicinal uses: E. Bombardelli, P. Morazzoni, Fitoterapia 66, 43-68 (1995). HPLC analysis and effect of cultivation on components: B. Büter et al., Planta Med. 64, 431 (1998). HPLC determn of constituents in dietary supplements: W. Li, J. F. Fitzloff, J. Chromatogr. B 765, 99 (2001). Pharmacology of extracts: S. Perovic, W. E. G. Müller, Arzneim.-Forsch. 45, 1145 (1995); J. T. Neary, Y. Bu, Brain Res. 816, 358 (1999). Clinical trial in comparison with imipramine for depression: M. Philipp et al., Br. Med. J. 319, 1534 (1999). Reviews of clinical experience: E. Ernst et al., Eur. J. Clin. Pharmacol. 54, 589-594 (1998); B. Gaster, J. Holroyd, Arch. Int. Med. 160, 152-156 (2000).
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