Title: Etofibrate
CAS Registry Number: 31637-97-5
CAS Name: 3-Pyridinecarboxylic acid 2-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl ester
Additional Names: nicotinic acid 2-hydroxyethyl ester 2-(p-chlorophenoxy)-2-methylpropionate (ester); ethylene glycol 1-[2-(p-chlorophenoxy)-2-methylpropionate]-2-nicotinate; a-[(p-chlorophenoxy)isobutyroyl]-b-(nicotinoyl)glycol; ethofibrate
Trademarks: Lipo-Merz (Merz)
Molecular Formula: C18H18ClNO5
Molecular Weight: 363.79
Percent Composition: C 59.43%, H 4.99%, Cl 9.75%, N 3.85%, O 21.99%
Literature References: Glycol diester of nicotinic and clofibric acids, q.q.v. Prepn: A. Scherm, D. Peteri, DE 1941217; eidem, US 3723446 (1971, 1973 both to Merz). Lipid lowering effects in rats: W. Sterner, A. Schultz, Arzneim.-Forsch. 24, 1990 (1974). Metabolism: H. Oelschläger et al., ibid. 30, 984 (1980). In vitro effect on human platelet function: M. P. Ortega et al., Thromb. Res. 19, 409 (1980). HPLC determn in plasma: E. R. Garrett, M. R. Gardner, J. Pharm. Sci. 71, 14 (1982). Bioavailability and pharmacokinetics in humans: K. I. Johnson et al., Arzneim.-Forsch. 34, 1785 (1984). Review of pharmacology and comparison with other hypolipidemic agents: R. Paoletti et al., Am. J. Cardiol. 52, Suppl B, 21B-27B (1983).
Properties: Crystalline powder, mp 100°.
Melting point: mp 100°
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates. |