Title: Acipimox
CAS Registry Number: 51037-30-0
CAS Name: 5-Methylpyrazinecarboxylic acid 4-oxide
Additional Names: 2-carboxy-5-methylpyrazine 4-oxide
Manufacturers' Codes: K-9321
Trademarks: Olbemox (Pharmacia); Olbetam (Pharmacia)
Molecular Formula: C6H6N2O3
Molecular Weight: 154.12
Percent Composition: C 46.76%, H 3.92%, N 18.18%, O 31.14%
Literature References: Prepn: V. Ambrogi et al., DE 2319834; eidem, US 4002750 (1973, 1977 both to Carlo Erba). Prepn and toxicology: eidem, Eur. J. Med. Chem. 15, 157 (1980). Pharmacological profile: P. P. Lovisolo et al., Pharmacol. Res. Commun. 13, 151, 163 (1981). Pharmacokinetics: L. M. Fuccella et al., Clin. Pharmacol. Ther. 28, 790 (1980); L. Musatti et al., J. Int. Med. Res. 9, 381 (1981). Mechanism of action: K. Aktories et al., Arzneim.-Forsch. 33, 1525 (1983).
Properties: Crystals from water, mp 177-180°. LD50 orally in mice: 3500 mg/kg (Ambrogi).
Melting point: mp 177-180°
Toxicity data: LD50 orally in mice: 3500 mg/kg (Ambrogi)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Nicotinic Acid Derivatives. |