Title: Ranpirnase
CAS Registry Number: 133737-96-9
CAS Name: Ribonuclease (Rana pipiens reduced)
Additional Names: P-30 protein
Trademarks: Onconase (Alfacell)
Literature References: Antitumor ribonuclease isolated from oocytes and early embryos of Rana pipiens. Single chain protein containing 104 amino acid residues; mol wt ~12 kDa. Description of cytotoxic activity: Z. Darzynkiewicz et al., Cell Tissue Kinet. 21, 169 (1988). Amino acid sequence and identification as a ribonuclease: W. Ardelt et al., J. Biol. Chem. 266, 245 (1991). Crystallization: S. C. Mosimann et al., Proteins: Struct. Funct. Genet. 14, 392 (1992). Mechanism of action: Y. Wu et al., J. Biol. Chem. 268, 10686 (1993). Prepn by recombinant technology: E. Notomista et al., FEBS Lett. 463, 211 (1999). Clinical trial in malignant mesothelioma: S. M. Mikulski et al., J. Clin. Oncol. 20, 274 (2002).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Enzymes. |