Title: Iopamidol
CAS Registry Number: 60166-93-0
CAS Name: N,N¢-Bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[[(2S)-2-hydroxy-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
Additional Names: (S)-N,N¢-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-5-lactamidoisophthalamide; 5-(a-hydroxypropionylamino)-2,4,6-triiodoisophthalic acid di(1,3-dihydroxyisopropylamide); iomapidol
Manufacturers' Codes: B-15000; SQ-13396
Trademarks: Iopamiro (Bracco); Iopamiron (Bracco); Isovue (BMS); Jopamiro (Bracco); Niopam (Bracco); Solutrast (Bracco)
Molecular Formula: C17H22I3N3O8
Molecular Weight: 777.09
Percent Composition: C 26.28%, H 2.85%, I 48.99%, N 5.41%, O 16.47%
Literature References: Nonionic radiocontrast medium. Prepn: E. Felder, D. Pitre, DE 2547789; eidem, US 4001323 (1976, 1977 both to Savac). Physicochemical properties, preclinical studies: E. Felder et al., Farmaco Ed. Sci. 32, 835 (1977). Determn of optical purity: eidem, Farmaco Ed. Prat. 32, 3 (1982). In vitro effects: B. Schulze, H. K. Beyer, Arzneim.-Forsch. 31, 1067 (1981). Development, initial testing: M. Sovak et al., Radiology 142, 115 (1982). Clinical studies in angiography: A. J. Molyneux, P. W. Sheldon, Br. J. Radiol. 55, 117 (1982); G. H. Whitehouse, S. L. Snowdon, Clin. Radiol. 33, 231 (1982); in myelography: B. Drayer et al., Am. J. Neuroradiol. 3, 59 (1982). Comprehensive description: E. Felder et al., Anal. Profiles Drug Subs. 17, 115-154 (1988).
Properties: White, odorless cryst powder. Dec at about 300° without melting. [a]D20 -2.01° (c = 10 in water). pKa (25°) 10.70. Very sol in water, methanol. Practically insol in chloroform. Miscible with boiling ethanol. LD50 in mice, rats, rabbits, dogs (g/kg): 44.5, 28.2, 19.6, 34.7 i.v. (Felder). Also reported as: LD50 in mice (mg iodine/kg body wt): 21,800 i.v.; 20,000 i.p.; 1500 intracerebral (Felder, Pitre).
pKa: pKa (25°) 10.70
Optical Rotation: [a]D20 -2.01° (c = 10 in water)
Toxicity data: LD50 in mice, rats, rabbits, dogs (g/kg): 44.5, 28.2, 19.6, 34.7 i.v. (Felder); LD50 in mice (mg iodine/kg body wt): 21,800 i.v.; 20,000 i.p.; 1500 intracerebral (Felder, Pitre).
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |