Calcium Cyanamide Citrated

Literature References: Contains citric acid in two parts by weight to one part of calcium cyanamide suitably purified for drug use. Used in treatment of alcoholism. Formulations: de Grunigen, Ferguson, US 2998350 (1961 to Cyanamid and Alcoholism Res. Found., Toronto). Acts by inhibiting aldehyde dehydrogenase: J. A. Smith et al., J. Am. Med. Assoc. 165, 2181 (1957). Effect on cardiovascular system: J. E. Peachey et al., Clin. Pharmacol. Ther. 29, 40 (1981); on liver cells: J. J. Vázquez, S. Cervera, Lancet 1, 361 (1980). Comparison with disulfiram, q.v.: M. S. Levy et al., Am. J. Psychiatry 123, 1018 (1967). Review of drug therapy for alcoholism: E. M. Sellers et al., N. Engl. J. Med. 305, 1255 (1981).