Title: Trepibutone
CAS Registry Number: 41826-92-0
CAS Name: 2,4,5-Triethoxy-g-oxobenzenebutanoic acid
Additional Names: 3-(2,4,5-triethoxybenzoyl)propionic acid
Manufacturers' Codes: AA-149
Trademarks: Supacal (Lederle)
Molecular Formula: C16H22O6
Molecular Weight: 310.34
Percent Composition: C 61.92%, H 7.15%, O 30.93%
Literature References: Prepn: T. Murata et al., DE 2244324 corresp to US 3943169 (1973, 1976 both to Takeda). Properties and stabilities: M. Mitani et al., Takeda Kenkyushoho 36, 206 (1977), C.A. 88, 126284f (1978). Pharmacokinetics: eidem, ibid. 215, C.A. 88, 115067m (1978). Biotransformation: T. Kobayashi et al., Xenobiotica 8, 535 (1978). Metabolism studies: S. Tanayama et al., ibid. 365, 377. Spasmolytic action in dogs: H. Satoh et al., Eur. J. Pharmacol. 48, 309 (1978). Mechanism of choleretic action: eidem, ibid. 125. Toxicity studies: S. Sato et al., Takeda Kenkyushoho 36, 263 (1977), C.A. 88, 11535x (1978).
Properties: Colorless needles from aq ethanol or plates from aq acetone, mp 150-151°. Stable to heat, humidity, indoor diffused sunlight. Aq solns heated to 100° for 10 hr showed no degradation.
Melting point: mp 150-151°
Therap-Cat: Choleretic; antispasmodic.
Keywords: Antispasmodic; Choleretic. |