Title: Bromadiolone
CAS Registry Number: 28772-56-7
CAS Name: 3-[3-(4¢-Bromo[1,1¢-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[a-[p-(p-bromophenyl)-b-hydroxyphenethyl]benzyl]-4-hydroxycoumarin
Manufacturers' Codes: LM-637
Trademarks: Maki (Lipha); Bromone (Lipha); Super-Caid (Lipha); Super-Rozol (Lipha)
Molecular Formula: C30H23BrO4
Molecular Weight: 527.41
Percent Composition: C 68.32%, H 4.40%, Br 15.15%, O 12.13%
Literature References: Anticoagulant rodenticide. Prepn: E. Boschetti et al., DE 1959317; eidem, US 3764693 (1970, 1973 both to Lipha). Activity studies: eidem, Chim. Ther. 7, 20 (1972); M. Grand, Phytiatr.-Phytopharm. 25, 69 (1976); R. E. Marsh, Bull. OEPP 7, 495 (1977); R. Redfern, J. E. Gill, J. Hyg. 84, 263 (1980). Pharmacokinetics: K. Nahas, Pharmacol. Res. Commun. 19, 767 (1987). HPLC determn of diastereoisomers in animal tissues: K. Hunter et al., J. Chromatogr. 435, 83 (1988).
Properties: White to offwhite powder, mp 200-210°. uv max (ethanol): 260 nm (E1%1cm 538-582). pKa (21°) 4.04. Soly at 20-25° (g/l): dimethylformamide 730.0; ethyl acetate 25.0; acetone 22.3; chloroform 10.1; ethanol 8.2; methanol 5.6; ethyl ether 3.7; hexane 0.2; water 0.019. LD50 in rats, mice (mg/kg): 1.125, 1.75 orally (Grand).
Melting point: mp 200-210°
pKa: pKa (21°) 4.04
Absorption maximum: uv max (ethanol): 260 nm (E1%1cm 538-582)
Toxicity data: LD50 in rats, mice (mg/kg): 1.125, 1.75 orally (Grand)
Use: Rodenticide. |