Title: Bimosiamose
CAS Registry Number: 187269-40-5
CAS Name: 3¢,3¢¢¢-(1,6-Hexanediyl)bis[6¢-(a-D-mannopyranosyloxy)[1,1¢-biphenyl]]-3-acetic acid
Additional Names: 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-a-D-mannopyranosyloxy)phenyl]hexane
Manufacturers' Codes: TBC-1269
Molecular Formula: C46H54O16
Molecular Weight: 862.91
Percent Composition: C 64.03%, H 6.31%, O 29.67%
Literature References: Pan-selectin receptor antagonist. Prepn: T. P. Kogan et al., WO 9701335; eidem, US 5919768 (1997, 1999 both to Texas Biotechnol.); eidem, J. Med. Chem. 41, 1099 (1998). Stereospecific synthesis: I. L. Scott et al., Carbohydr. Res. 317, 210 (1999). Review of pharmacology and clinical development: L. Pradella, Curr. Opin. Anti-Inflam. Immunomod. Invest. Drugs 1, 56-60 (1999); E. Aydt, G. Wolff, Pathobiology 70, 297-301 (2003). Clinical pharmacokinetics: M. Meyer et al., Int. J. Clin. Pharmacol. Ther. 43, 463 (2005). Clinical evaluation in allergic asthma: K. M. Beeh et al., Pulm. Pharmacol. Ther. 19, 233 (2006).
Properties: White solid, mp 115-117°.
Melting point: mp 115-117°
Derivative Type: Disodium salt
CAS Registry Number: 187269-60-9
Manufacturers' Codes: TBC-1269z
Molecular Formula: C46H52Na2O16
Molecular Weight: 906.88
Percent Composition: C 60.92%, H 5.78%, Na 5.07%, O 28.23%
Properties: Slightly hygroscopic white powder, mp 243-245°.
Melting point: mp 243-245°
Therap-Cat: Anti-inflammatory
Keywords: Anti-inflammatory (Biological Response Modifier). |