Beractant

Literature References: Organic solvent extract of bovine lung, consisting mostly of phospholipids, modified by the addition of colfosceril palmitate, palmitic acid and tripalmitin. Prepn: JP 83 45299; Y. Tanaka et al., US 4397839 (both 1983 to Tokyo Tanabe). Effect of protein component on surface activity: S. B. Hall et al., Am. Rev. Respir. Dis. 145, 24 (1992). Pharmacology: J. J. Cummings et al., ibid. 999. Metabolism in rabbits: J. F. Lewis et al., ibid. 19. Evaluation of establishment of normal surfactant function in comparison with Exosurf: E. M. Scarpelli et al., Am. J. Perinatol. 9, 414 (1992). Clinical trial in neonatal respiratory distress syndrome: M. D. Reller et al., Am. J. Dis. Child. 145, 1017 (1991); E. M. Zola et al., Pediatrics 91, 546 (1993).