Title: Trifluperidol
CAS Registry Number: 749-13-3
CAS Name: 1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-1-butanone
Additional Names: 4¢-fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]butyrophenone; p-fluoro-4-[4¢-hydroxy-4¢-(3¢¢-trifluoromethyl)phenyl]piperidinobutyrophenone; 1-(3¢-p-fluorobenzoylpropyl)-4-hydroxy-4-(3¢¢-trifluoromethylphenyl)piperidine; w-[4-hydroxy-4-(m-trifluoromethylphenyl)piperidino]-p-fluorobutyrophenone; flumoperone
Molecular Formula: C22H23F4NO2
Molecular Weight: 409.42
Percent Composition: C 64.54%, H 5.66%, F 18.56%, N 3.42%, O 7.82%
Literature References: Prepn: P. A. J. Janssen, GB 895309; idem, US 3438991 (1962, 1969 both to Janssen). Pharmacology: idem, Arzneim.-Forsch. 11, 932 (1961).
Derivative Type: Hydrochloride
CAS Registry Number: 2062-77-3
Manufacturers' Codes: R-2498
Trademarks: Psicoperidol (Lusofarmaco); Psychoperidol (Ethnor); Triperidol (Janssen)
Molecular Formula: C22H23F4NO2.HCl
Molecular Weight: 445.88
Percent Composition: C 59.26%, H 5.43%, F 17.04%, N 3.14%, O 7.18%, Cl 7.95%
Properties: Crystals from acetone, mp 200.5-201.3°. Sol in water. LD50 in rats (mg/kg): 14 i.v.; 70 s.c. (Janssen, 1961).
Melting point: mp 200.5-201.3°
Toxicity data: LD50 in rats (mg/kg): 14 i.v.; 70 s.c. (Janssen, 1961)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Butyrophenones. |