Title: Ticarcillin
CAS Registry Number: 34787-01-4
CAS Name: (2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Additional Names: N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic acid; 6-[D(-)-a-carboxy-3-thienylacetamido]penicillanic acid; a-carboxy-3-thienylmethylpenicillin
Molecular Formula: C15H16N2O6S2
Molecular Weight: 384.43
Percent Composition: C 46.86%, H 4.20%, N 7.29%, O 24.97%, S 16.68%
Literature References: Broad spectrum semi-synthetic antibiotic related to penicillin. Prepn: BE 646991; E. G. Brain, J. H. Nayler, US 3282926 (1964, 1966 to Beecham Group Ltd.). In vitro studies: H. C. Neu, E. B. Winshell, Antimicrob. Agents Chemother. 1970, 385; R. Sutherland et al., ibid. 390; N. J. Legakis, J. Papavassiliou, J. Antibiot. 28, 912 (1975). In vivo studies: P. Acred et al., Antimicrob. Agents Chemother. 1970, 396. Absorption and excretion: R. Sutherland, P. J. Wise, ibid. 402. Clinical pharmacology: V. Rodriguez et al., Antimicrob. Agents Chemother. 4, 31 (1973); R. D. Libke et al., Clin. Pharmacol. Ther. 17, 441 (1975). Review of pharmacology and therapeutic efficacy: R. N. Brogden et al., Drugs 20, 325-352 (1980).
Derivative Type: Disodium salt
CAS Registry Number: 4697-14-7
Manufacturers' Codes: BRL-2288
Trademarks: Monapen (Fujisawa); Ticar (GSK); Ticarpen (GSK); Ticillin (CSL)
Molecular Formula: C15H14N2Na2O6S2
Molecular Weight: 428.39
Percent Composition: C 42.06%, H 3.29%, N 6.54%, Na 10.73%, O 22.41%, S 14.97%
Properties: Creamy-white hygroscopic non-crystalline powder. Readily sol in water (>100 g/100 ml water) giving a clear soln with pH between 6.0 and 8.0. Aq solns are relatively stable; acid solns relatively unstable (Sutherland).
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins. |