Title: Voglibose
CAS Registry Number: 83480-29-9
CAS Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epiinositol
Additional Names: N-(1,3-dihydroxy-2-propyl)valiolamine
Manufacturers' Codes: AO-128
Trademarks: Basen (Takeda)
Molecular Formula: C10H21NO7
Molecular Weight: 267.28
Percent Composition: C 44.94%, H 7.92%, N 5.24%, O 41.90%
Literature References: a-Glucosidase inhibitor. Prepn: S. Horii et al., EP 56194; eidem, US 4701559 (1982, 1987 both to Takeda); and structure-activity study: eidem et al., J. Med. Chem. 29, 1038 (1986). Synthesis: H. Fukase, S. Horii, J. Org. Chem. 57, 3651 (1992). Enzyme inhibition and pharmacology: T. Matsuo et al., Am. J. Clin. Nutr. 55, 314S (1992). Clinical pharmacology: B. Göke et al., Digestion 56, 493 (1995). Clinical evaluation in hyperinsulinemia: K. Shinozaki et al., Metabolism 45, 731 (1996).
Properties: Colorless crystals, mp 162-163°. [a]D25 +26.2° (c = 1 in water).
Melting point: mp 162-163°
Optical Rotation: [a]D25 +26.2° (c = 1 in water)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; a-Glucosidase Inhibitor. |