Title: Teclothiazide
CAS Registry Number: 4267-05-4
CAS Name: 6-Chloro-3,4-dihydro-3-trichloromethyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Additional Names: 6-chloro-3,4-dihydro-7-sulfamoyl-3-trichloromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3-trichloromethylhydrochlorothiazide; tetrachlormethiazide
Molecular Formula: C8H7Cl4N3O4S2
Molecular Weight: 415.10
Percent Composition: C 23.15%, H 1.70%, Cl 34.16%, N 10.12%, O 15.42%, S 15.45%
Literature References: Prepn: Close et al., J. Am. Chem. Soc. 82, 1132 (1960); Novello et al., J. Org. Chem. 25, 970 (1960). Pharmacology and toxicology: M. Auclair et al., Therapie 18, 131, 137 (1963).
Properties: Crystals, mp 300-303° (Close); mp 287° (Novello).
Melting point: mp 300-303° (Close); mp 287° (Novello)
Derivative Type: Potassium salt
CAS Registry Number: 5306-80-9
Manufacturers' Codes: PS-207; K-33
Trademarks: Depleil (Promedica)
Molecular Formula: C8H6Cl4KN3O4S2
Molecular Weight: 453.19
Percent Composition: C 21.20%, H 1.33%, Cl 31.29%, K 8.63%, N 9.27%, O 14.12%, S 14.15%
Properties: LD50 i.p. in mice: 4.75 g/kg (Auclair).
Toxicity data: LD50 i.p. in mice: 4.75 g/kg (Auclair)
Therap-Cat: Diuretic.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs. |