Title: Pimefylline
CAS Registry Number: 10001-43-1
CAS Name: 3,7-Dihydro-1,3-dimethyl-7-[2-[(3-pyridinylmethyl)amino]ethyl]-1H-purine-2,6-dione
Additional Names: 7-[2-[(3-pyridylmethyl)amino]ethyl]theophylline; 7-(b-3¢-picolylaminoethyl)theophylline; pimephylline
Manufacturers' Codes: ES-771
Molecular Formula: C15H18N6O2
Molecular Weight: 314.34
Percent Composition: C 57.31%, H 5.77%, N 26.74%, O 10.18%
Literature References: Prepn: NL 6600250; Suter, Zutter, US 3350400 (1966, 1967 both to Eprova). Structure determn, properties and chemistry: eidem, Pharm. Acta Helv. 48, 133 (1973). Pharmacology: Ciaceri, Attaguile, Gazz. Med. Ital. 132, 36, 108 (1973). Metabolism: Pitrè, Farmaco Ed. Prat. 29, 46 (1974).
Properties: Crystals from isopropyl acetate, mp 111-112°. uv max (water): 270 nm. Readily sol in cold water, chloroform; sol in acetone, ethanol. LD50 in mice (mg/kg): 1900 orally, 402 i.v. (Suter, Zutter, 1973).
Melting point: mp 111-112°
Absorption maximum: uv max (water): 270 nm
Toxicity data: LD50 in mice (mg/kg): 1900 orally, 402 i.v. (Suter, Zutter, 1973)
Derivative Type: Nicotinate
CAS Registry Number: 10058-07-8
Manufacturers' Codes: ES-902
Trademarks: Teonicon (Neopharmed)
Molecular Formula: C15H18N6O2.C6H5NO2
Molecular Weight: 437.45
Percent Composition: C 57.66%, H 5.30%, N 22.41%, O 14.63%
Properties: Colorless, odorless powder from ethanol, mp 159-160°. uv max (water): 267 nm. Very sol in water (40% soln can be prepd); slightly sol in methanol; very slightly sol in acetone, chloroform. LD50 in mice (mg/kg): 2530 orally, 470 i.v. (Suter, Zutter, 1973).
Melting point: mp 159-160°
Absorption maximum: uv max (water): 267 nm
Toxicity data: LD50 in mice (mg/kg): 2530 orally, 470 i.v. (Suter, Zutter, 1973)
Therap-Cat: Vasodilator (coronary).
Keywords: Vasodilator (Coronary). |