Title: Ramatroban
CAS Registry Number: 116649-85-5
CAS Name: (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
Additional Names: (+)-(3R)-3-(p-fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid; (+)-3-(4-fluorophenylsulfonamido)-9-(2-carboxyethyl)-1,2,3,4-tetrahydrocarbazole
Manufacturers' Codes: Bay u 3405
Trademarks: Baynas (Bayer)
Molecular Formula: C21H21FN2O4S
Molecular Weight: 416.47
Percent Composition: C 60.56%, H 5.08%, F 4.56%, N 6.73%, O 15.37%, S 7.70%
Literature References: Thromboxane A2 receptor antagonist. Prepn: H. Böshagen et al., DE 3631824; eidem, US 4965258 (1988, 1990 both to Bayer); and absolute configuration: U. Rosentreter et al., Arzneim.-Forsch. 39, 1519 (1989). Series of articles on pharmacology: ibid. 1522-1530. Clinical evaluation in asthma: H. Aizawa et al., Chest 109, 338 (1996).
Properties: Crystals from ether, mp 134-135°. [a]D +70.1° (c = 1.0 in methanol).
Melting point: mp 134-135°
Optical Rotation: [a]D +70.1° (c = 1.0 in methanol)
Therap-Cat: Antiasthmatic; antiallergic.
Keywords: Antiallergic; Antiasthmatic (Nonbronchodilator); Thromboxane A2-Receptor Antagonist. |