Title: Perfosfamide
CAS Registry Number: 62435-42-1; 39800-16-3 (unspecified stereo)
CAS Name: rel-(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide
Additional Names: cis-(±)-2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; cis-4-hydroperoxycyclophosphamide; 4-HC
Manufacturers' Codes: NSC-181815
Trademarks: Pergamid (Scios-Nova)
Molecular Formula: C7H15Cl2N2O4P
Molecular Weight: 293.08
Percent Composition: C 28.69%, H 5.16%, Cl 24.19%, N 9.56%, O 21.84%, P 10.57%
Literature References: Prepn (stereochem. unspecified): NL 7208895; A. Takamizawa, T. Iwata, US 3808297 (1972, 1974 both to Shionogi); idem et al., J. Am. Chem. Soc. 95, 985 (1973). Structural study: A. Camerman et al., Acta Crystallogr. B33, 678 (1977). Cytostatic activity: A. Takamizawa et al., J. Med. Chem. 18, 376 (1975). Clinical use: D. Biggs et al., Prog. Clin. Biol. Res. 389, 9 (1994). Review of use as purging agent in autologous bone marrow transplantation: A. M. Yeager et al., Am. J. Pediatr. Hematol. Oncol. 12, 245-256 (1990); R. J. Jones, J. Hematother. 1, 343-348 (1992).
Properties: White crystals from acetone/ether (unspecified form). mp 107-108°. LD50 in rats, mice (mg/kg): 115, 235 i.v.; 131, 181 i.p. (Takamizawa, 1975).
Melting point: mp 107-108°
Toxicity data: LD50 in rats, mice (mg/kg): 115, 235 i.v.; 131, 181 i.p. (Takamizawa, 1975)
Therap-Cat: Antineoplastic; bone marrow purging agent.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards. |