Title: Nefopam
CAS Registry Number: 13669-70-0
CAS Name: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine
Additional Names: 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine
Molecular Formula: C17H19NO
Molecular Weight: 253.34
Percent Composition: C 80.60%, H 7.56%, N 5.53%, O 6.32%
Literature References: A cyclized analog of orphenadrine and diphenhydramine, q.q.v.; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Prepn: NL 6606390 (1966 to Rexall); M. W. Klohs et al., US 3830803 (1974 to Riker). Pharmacology: Bassett et al., Br. J. Pharmacol. 37, 69 (1969); Klohs et al., Arzneim.-Forsch. 22, 132 (1972). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 19, 249-267 (1980).
Derivative Type: Hydrochloride
CAS Registry Number: 23327-57-3
Additional Names: Fenazoxine
Manufacturers' Codes: R-738
Trademarks: Acupan (3M); Ajan (3M)
Molecular Formula: C17H19NO.HCl
Molecular Weight: 289.80
Percent Composition: C 70.46%, H 6.96%, N 4.83%, O 5.52%, Cl 12.23%
Properties: mp 238-242°. LD50 in mice, rats (mg/kg): 119, 178 orally; 44.5, 28 i.v. (Baltes).
Melting point: mp 238-242°
Toxicity data: LD50 in mice, rats (mg/kg): 119, 178 orally; 44.5, 28 i.v. (Baltes)
Therap-Cat: Analgesic; antidepressant.
Keywords: Analgesic (Non-Narcotic); Antidepressant; Bicyclics. |