Title: Ecabapide
CAS Registry Number: 104775-36-2
CAS Name: 3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]-N-methylbenzamide
Additional Names: m-[[[(3,4-dimethoxyphenethyl)carbamoyl]methyl]amino]-N-methylbenzamide; ecabamide
Manufacturers' Codes: DQ-2511
Molecular Formula: C20H25N3O4
Molecular Weight: 371.43
Percent Composition: C 64.67%, H 6.78%, N 11.31%, O 17.23%
Literature References: a2-Adrenoceptor agonist; reduces vagally-induced gastric acid secretion. Prepn: T. Miki et al., EP 185368; eidem, US 4985595 (1986, 1991 both to Daiichi); T. Hosokami et al., Chem. Pharm. Bull. 40, 2712 (1992). Pharmacology: K. Yokotani et al., Jpn. J. Pharmacol. 48, 299 (1988); M. Hirohashi et al., Arzneim.-Forsch. 43, 569 (1993). Efficacy in exptl ulcers: M Asano et al., ibid. 40, 276 (1990). Metabolism studies: Y. Fujimaki et al., Xenobiotica 25, 501 (1995).
Properties: Colorless needles from methanol/diethyl ether, mp 93-96.5°; recrystallized as colorless prisms from abs methanol, mp 133-134.5°. Soly (mg/ml) in water: 5.31 at 25°, 8.55 at 37°.
Melting point: mp 93-96.5°; mp 133-134.5°
Therap-Cat: Antiulcerative.
Keywords: a-Adrenergic Agonist; Antiulcerative. |