Title: Methyl Cellosolve® (Carbide and Carbon Chem.)
CAS Registry Number: 109-86-4
CAS Name: 2-Methoxyethanol
Additional Names: ethylene glycol monomethyl ether
Molecular Formula: C3H8O2
Molecular Weight: 76.09
Percent Composition: C 47.35%, H 10.60%, O 42.05%
Line Formula: HOCH2CH2OCH3
Literature References: Prepn from ethylene oxide + methanol: Finch, Hagemeyer, US 2748171 (1956 to Kodak); from ethylene glycol + diazomethane: Hesse, Majumdar, Ber. 93, 1129 (1960). Toxicity data: Smyth, J. Ind. Hyg. Toxicol. 23, 259 (1941); Werner, ibid. 25, 157 (1943). Series of articles on toxicology: Environ. Health Perspect. 57, 1-275 (1984).
Properties: Liquid. Poisonous! bp760 124.43°; bp20 34-41°. d420 0.9663. Flash pt 115°F. nD20 1.4028. Miscible with water, alcohol ether, glycerol, acetone, dimethylformamide. LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth). LC50 (7 hr in air) in mice: 4.6 mg/l (Werner).
Boiling point: bp760 124.43°; bp20 34-41°
Flash point: Flash pt 115°F
Index of refraction: nD20 1.4028
Density: d420 0.9663
Toxicity data: LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth); LC50 (7 hr in air) in mice: 4.6 mg/l (Werner)
CAUTION: Potential symptoms of overexposure are irritation of eyes, nose, throat; headache, drowsiness, weakness; ataxia, tremor, somnolence; anemic pallor. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 202. Exerts principle toxic effects on brain, blood, kidneys, thymus, testes. Appreciably toxic when inhaled. Absorbed through skin; direct contact may cause skin irritation. Embryotoxic and teratogenic in exptl animals. See Patty's Industrial Hygiene and Toxicology vol. 2D, G. D. Clayton, F. E. Clayton, Eds. (Wiley-Interscience, New York, 4th ed., 1994) pp 2764-2776.
Use: Solvent for low-viscosity cellulose acetate, natural resins, some synthetic resins and some alcohol-soluble dyes; in dyeing leather, sealing moistureproof cellophane; in nail polishes, quick-drying varnishes and enamels, wood stains. In modified Karl Fischer reagent: Peters, Jungnickel, Anal. Chem. 27, 450 (1955). |