Title: Epsiprantel
CAS Registry Number: 98123-83-2
CAS Name: 2-(Cyclohexylcarbonyl)-2,3,6,7,8,12b-hexahydropyrazino[2,1-a][2]benzazepin-4(1H)-one
Additional Names: 2-cyclohexylcarbonyl-4-oxo-1,2,3,4,6,7,12b-octahydropyrazino[2,1-a][2]benzazepine
Manufacturers' Codes: BRL-38705
Trademarks: Cestex (SKB)
Molecular Formula: C20H26N2O2
Molecular Weight: 326.43
Percent Composition: C 73.59%, H 8.03%, N 8.58%, O 9.80%
Literature References: Anthelmintic structurally related to praziquantel, q.v. Prepn: R. J. Dorgan, R. L. Elliott, EP 134984; eidem, US 4661489 (1985, 1987 both to Beecham); M. D. Brewer et al., J. Med. Chem. 32, 2058 (1989). Veterinary trials in dogs: R. M. Corwin et al., Am. J. Vet. Res. 50, 1076 (1989); in cats and dogs: B. R. Manger, M. D. Brewer, Br. Vet. J. 145, 384 (1989).
Properties: White crystals from chloroform/petr ether, mp 189-190°.
Melting point: mp 189-190°
Therap-Cat-Vet: Anthelmintic (Cestodes). |