Title: Carbofuran
CAS Registry Number: 1563-66-2
CAS Name: 2,3-Dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate
Additional Names: methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester; 2,2-dimethyl-2,3-dihydro-7-benzofuranyl-N-methylcarbamate; 2,2-dimethyl-7-coumaranyl N-methylcarbamate
Manufacturers' Codes: Bay 70143; NIA-10242
Trademarks: Furadan (FMC)
Molecular Formula: C12H15NO3
Molecular Weight: 221.25
Percent Composition: C 65.14%, H 6.83%, N 6.33%, O 21.69%
Literature References: Cholinesterase inhibitor. Prepn and use as insecticide: NL 6407316 (1964 to Bayer), C.A. 63, 583a (1965); NL 6500340; W. G. Scharpf, US 3474170; US 3474171 (1965, 1969, 1969 all to FMC); E. F. Orwoll, US 3356690 (1967 to FMC). Metabolism: H. W. Dorough, J. Agric. Food Chem. 16, 319 (1968); J. B. Knaak, ibid. 18, 832 (1970). Toxicity studies: J. S. Tobin, J. Occup. Med. 12, 16 (1970); M. A. Fahmy et al., J. Agric. Food Chem. 18, 793 (1970). Teratogenicity study: K. D. Courtney et al., J. Environ. Sci. Health B20, 373 (1985).
Properties: White crystalline solid, mp 150-153°. Soly in water at 25°: 700 ppm. Unstable in alk. LD50 orally in mice: 2 mg/kg (Fahmy, 1970).
Melting point: mp 150-153°
Toxicity data: LD50 orally in mice: 2 mg/kg (Fahmy, 1970)
CAUTION: Potential symptoms of overexposure are miosis, blurred vision; sweating, salivation, abdominal cramps, diarrhea, headache, nausea, vomiting, weakness; muscle twitching, incoordination, convulsions. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 52; Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, p 305.
Use: Systemic insecticide, acaricide, nematocide. |