Title: Aluminum Hydroxychloride
CAS Registry Number: 1327-41-9
CAS Name: Basic aluminum chloride
Additional Names: aluminum chlorohydroxide; aluminum chlorohydrate
Trademarks: Chlorhydrol (Reheis); Hyperdrol (Britcair); Locron (Hoechst); Phosphonorm (Medice)
Literature References: The generally accepted empirical formula is Al2(OH)5Cl.2H2O. Prepd by electrolyzing solns of suitable Al salts: FR 837862 and GB 509815 (both 1939 to I. G. Farben.); H. Huehn, W. Haufe, US 2392531 (1946); Andersen, US 2492085 (1949 to Elizabeth Arden). Structural studies and physicochemical properties: D. L. Teagarden et al., J. Pharm. Sci. 70, 758, 762 (1981). Phosphate binding activity and use in hyperphosphatemia: DE 3147869 (1983 to Nefro-Pharma), C.A. 99, 110747a (1983).
Properties: Glassy solid. Dissolves in water, forming slightly turbid colloidal solns (up to 55% w/w). pH of 15% aq soln ~4.3.
Use: In antiperspirants.
Therap-Cat: Astringent; antihyperphosphatemic.
Keywords: Antihyperphosphatemic; Astringent. |