Title: Zaleplon
CAS Registry Number: 151319-34-5
CAS Name: N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
Manufacturers' Codes: CL-284846
Trademarks: Sonata (Wyeth)
Molecular Formula: C17H15N5O
Molecular Weight: 305.33
Percent Composition: C 66.87%, H 4.95%, N 22.94%, O 5.24%
Literature References: Selective non-benzodiazepine GABAA receptor agonist. Prepn: J. P. Dusza et al., US 4626538 (1986 to Am. Cyanamid). Clinical pharmacology: D. Allen et al., Eur. J. Clin. Pharmacol. 45, 313 (1993); B. Beer et al., J. Clin. Pharmacol. 34, 335 (1994). Clinical pharmacokinetics: A. S. Rosen et al., Biopharm. Drug Dispos. 20, 171 (1999). Clinical comparison with zolpidem, q.v.: R. Elie et al., J. Clin. Psychiatry 60, 536 (1999). CE-LIF determn of metabolites in urine: C. Horstkötter et al., J. Chromatogr. A 1014, 71 (2003). Review of pharmacology and clinical experience: W. E. Heydorn, Expert Opin. Invest. Drugs 9, 841-858 (2000).
Properties: White to off-white powder. mp 186-187°. Log P (octanol/water): 1.23 (pH 1-7). Sparingly sol in alcohol, propylene glycol. Practically insol in water.
Melting point: mp 186-187°
Log P: Log P (octanol/water): 1.23 (pH 1-7)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Imidazopyridines. |