Title: Telmisartan
CAS Registry Number: 144701-48-4
CAS Name: 4¢-[(1,4¢-Dimethyl-2¢-propyl[2,6¢-bi-1H-benzimidazol]-1¢-yl)methyl][1,1¢-biphenyl]-2-carboxylic acid
Additional Names: 4¢-[[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
Manufacturers' Codes: BIBR 277
Trademarks: Kinzalmono (Bayer); Micardis (Boehringer, Ing.); Pritor (GSK)
Molecular Formula: C33H30N4O2
Molecular Weight: 514.62
Percent Composition: C 77.02%, H 5.88%, N 10.89%, O 6.22%
Literature References: Angiotensin II receptor antagonist. Prepn: N. Hauel et al., EP 502314 (1992 to Thomae), C.A. 117, 251352 (1992); U. J. Ries et al., J. Med. Chem. 36, 4040 (1993). Pharmacology: W. Wienen et al., Br. J. Pharmacol. 110, 245 (1993). Binding study: W. Wienen, M. Entzeroth, J. Hypertens. 12, 119 (1994). Clinical pharmacology, pharmacokinetics: J. M. Neutel, D. H. G. Smith, Adv. Ther. 15, 206 (1998). Clinical trial in hypertension: D. H. G. Smith et al., ibid. 229. Review of pharmacology and clinical efficacy: K. J. McClellan, A. Markham, Drugs 56, 1039-1044 (1998).
Properties: White solid, mp 261-263°. Practically insol in water (pH 3-9). Sparingly sol in strong acid (except insol in hydrochloric acid); sol in strong base.
Melting point: mp 261-263°
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive. |