Title: Sinapultide
CAS Registry Number: 138531-07-4
Manufacturers' Codes: KL4
Molecular Formula: C126H238N26O22
Molecular Weight: 2469.40
Percent Composition: C 61.28%, H 9.71%, N 14.75%, O 14.25%
Literature References: Synthetic pulmonary surfactant protein consisting of 21 amino acid residues in a repeating sequence of one lysine and four leucines. Mimics surfactant protein-B (SP-B), a naturally occurring, hydrophobic protein found in human lung surfactant. Prepn: C. G. Cochrane, S. D. Revak, WO 9222315; eidem, US 5407914 (1992, 1995 both to Scripps Res. Inst.). Surface behavior in phospholipid systems: J. Ma et al., Biophys. J. 74, 1899 (1998).
Derivative Type: Lucinactant
Additional Names: KL4-surfactant
Trademarks: Surfaxin (Discovery Labs)
Literature References: Mixture of sinapultide with dipalmitoyl phosphatidylcholine and palmitoyl oleoylphosphatidyl glycerol (3:1) and palmitic acid. Effect on pulmonary function in animal models of meconium aspiration syndrome: C. G. Cochrane et al., Pediatr. Res. 44, 705 (1998). Clinical evaluation in meconium aspiration syndrome: T. E. Wiswell et al., Pediatrics 109, 1081 (2002). Clinical trial in premature infant respiratory distress syndrome: S. K. Sinha et al., ibid. 115, 1030 (2005). Review of chemistry and clinical experience: S. M. Donn, Expert Opin. Invest. Drugs 14, 329-334 (2005).
Therap-Cat: Pulmonary surfactant; in treatment of respiratory distress syndrome. |