Title: Sertindole
CAS Registry Number: 106516-24-9
CAS Name: 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
Additional Names: 5-chloro-1-(4-fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidyl]-1H-indole
Manufacturers' Codes: Lu-23-174
Trademarks: Serdolect (Lundbeck)
Molecular Formula: C24H26ClFN4O
Molecular Weight: 440.94
Percent Composition: C 65.37%, H 5.94%, Cl 8.04%, F 4.31%, N 12.71%, O 3.63%
Literature References: Combined dopamine (D2) and serotonin (5-HT2) receptor antagonist. Prepn: J. K. Perregaard, EP 200322; idem, US 4710500 (1986, 1987 both to Lundbeck); idem et al., J. Med. Chem. 35, 1092 (1992). Neuropharmacology and receptor binding study: C. Sanchez et al., Drug Dev. Res. 22, 239 (1991). Reviews of clinical efficacy and safety: J. M. Kane, Int. Clin. Psychopharmacol. 13, Suppl. 3, S59-S64 (1997); A. S. Hale, ibid. S65-S70.
Properties: Crystals from acetone, mp 154-155°. Second crystal modification from 2-propanol + ethyl acetate, mp 166°.
Melting point: mp 154-155°; mp 166°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Serotonin-Dopamine Antagonist. |