Title: Propargyl Alcohol
CAS Registry Number: 107-19-7
CAS Name: 2-Propyn-1-ol
Molecular Formula: C3H4O
Molecular Weight: 56.06
Percent Composition: C 64.27%, H 7.19%, O 28.54%
Line Formula: HCºCCH2OH
Literature References: Prepd by heating b-bromoallyl alcohol with conc KOH: Henry, Ber. 5, 456, 569 (1872); 6, 729 (1873); 14, 404 (1881); from formaldehyde and sodium acetylide: Henne, Greenlee, J. Am. Chem. Soc. 67, 484 (1945); from epichlorohydrin + sodium: Eglinton et al., J. Chem. Soc. 1952, 2873; from acetylene and formaldehyde: Reppe, Ann. 596, 1 (1955). Toxicity study: W. Guilian, B. Naibin, Chemosphere 36, 1475 (1998).
Properties: Moderately volatile liquid. Mild geranium odor. d420 0.9715. mp -52 to -48°. bp760 114-115°; bp490.3 100°; bp147.6 70°; bp35.4 40°; bp20.6 30°; bp11.6 20°. nD20 1.43064. Viscosity at 20° = 1.68 cP. Flash pt 33°C. Spec heat: 0.616 cal/g. Misc with water, benzene, chloroform, 1,2-dichloroethane, ethanol, ether, acetone, dioxane, tetrahydrofuran, pyridine. Appreciable heat is evolved on mixing with pyridine. Moderately sol in carbon tetrachloride. Immiscible with aliphatic hydrocarbons. With water, propargyl alcohol forms an azeotrope, bp 97.5°. This mixture has a composition of 39.5 parts by weight of propargyl alcohol and 60.5 parts of water. Polymerized by heat or caustic. Acidified aq solns are resistant to polymerization. LD50 in rats, mice (mg/kg): 20, 50 orally (Guilian, Naibin).
Melting point: mp -52 to -48°
Boiling point: bp760 114-115°; bp490.3 100°; bp147.6 70°; bp35.4 40°; bp20.6 30°; bp11.6 20°; bp 97.5°
Flash point: Flash pt 33°C
Index of refraction: nD20 1.43064
Density: d420 0.9715
Toxicity data: LD50 in rats, mice (mg/kg): 20, 50 orally (Guilian, Naibin)
CAUTION: Potential symptoms of overexposure are irritation of skin, mucous membranes; CNS depression. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 264. |