Title: Primidone
CAS Registry Number: 125-33-7
CAS Name: 5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione
Additional Names: 5-ethyl-5-phenylhexahydropyrimidine-4,6-dione; 2-desoxyphenobarbital
Trademarks: Liskantin (Desitin); Mylepsinum (AWD); Mysoline (Acorus); Resimatil (Sanofi-Synthelabo); Sertan (Valeant)
Molecular Formula: C12H14N2O2
Molecular Weight: 218.25
Percent Composition: C 66.04%, H 6.47%, N 12.84%, O 14.66%
Literature References: Prepd by electrolytic reduction of phenobarbital or by catalytic desulfuration of the corresp 2-thiobarbituric acid: Boon et al., GB 666027 (1952 to I.C.I.); Bogue, Carrington, Br. J. Pharmacol. 8, 230 (1953). Comprehensive description: R. D. Daley in Anal. Profiles Drug Subs. 2, 409-437 (1973); A. A. Al-Badr, H. A. El-Obeid, ibid. 17, 749-795 (1988). HPLC determn in urine: V. Ferranti et al., J. Chromatogr. B 718, 199 (1998). Clinical trial in essential tremor: M. Serrano-Dueñas, Parkinsonism Relat. Disord. 10, 29 (2003).
Properties: Crystals, mp 281-282°. Practically tasteless. Has no acidic properties. Sparingly sol in water (0.6 g/l at 37°); in most organic solvents.
Melting point: mp 281-282°
Therap-Cat: Anticonvulsant.
Therap-Cat-Vet: Anticonvulsant. Chiefly to control epileptiform seizures.
Keywords: Anticonvulsant. |