Title: Prazosin
CAS Registry Number: 19216-56-9
CAS Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
Additional Names: 2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline; furazosin
Molecular Formula: C19H21N5O4
Molecular Weight: 383.40
Percent Composition: C 59.52%, H 5.52%, N 18.27%, O 16.69%
Literature References: a1-Adrenergic blocker. Prepn: GB 1156973; Hess, US 3511836 (1969, 1970 both to Pfizer); NL 7206067 (1972 to Brocades-Stheeman), C.A. 78, 72180s (1973); E. Honkanen et al., J. Heterocycl. Chem. 17, 797 (1980). Pharmacology and clinical data: Scriabine et al., Experientia 24, 1150 (1968); Cohen, J. Clin. Pharmacol. J. New Drugs 10, 408 (1970). Pharmacokinetics: P. Jaillon, Clin. Pharmacokinet. 5, 365 (1980). HPLC determn in biological fluids: R. K. Bhamra et al., J. Chromatogr. 380, 216 (1986). Clinical evaluation in Raynaud's phenomenon: I. J. Russell, J. A Lessard, J. Rheumatol. 12, 94 (1985); in dysuria with benign prostatic hypertrophy: A. LeDuc et al., Urol. Int. 45, Suppl. 1, 56 (1990). Book: Prazosin: Pharmacology, Hypertension and Congestive Heart Failure, M. D. Rawlins, Ed. (Grune & Stratton, New York, 1981) 143 pp. Review of pharmacology and therapeutic use: W. F. Stanaszek et al., Drugs 25, 339-384 (1983); J. L. Reid, J. Vincent, Cardiology 73, 164-174 (1986). Comprehensive description: L. J. Kostek, Anal. Profiles Drug Subs. 18, 351-378 (1989).
Properties: Crystals, mp 278-280°.
Melting point: mp 278-280°
Derivative Type: Hydrochloride
CAS Registry Number: 19237-84-4
Manufacturers' Codes: CP-12299-1
Trademarks: Alpress LP (Pfizer); Duramipress (Durachemie); Eurex (Labaz); Hypovase (Pfizer); Minipress (Pfizer); Peripress (Pfizer); Sinetens (Erba)
Molecular Formula: C19H21N5O4.HCl
Molecular Weight: 419.86
Percent Composition: C 54.35%, H 5.28%, N 16.68%, O 15.24%, Cl 8.44%
Properties: uv max (methanolic 0.01N HCl): 246, 329 nm (aM 137 ±3, 27.6 ±0.3). Soly at ambient temp (mg/ml): acetone 0.0072, methanol 6.4, ethanol 0.84, dimethylformamide 1.3, dimethylacetamide 1.2, water (pH~3.5) 1.4, chloroform 0.041.
Absorption maximum: uv max (methanolic 0.01N HCl): 246, 329 nm (aM 137 ±3, 27.6 ±0.3)
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Blocker; Antihypertensive; Quinazoline Derivatives. |