Title: Polyestradiol Phosphate
CAS Registry Number: 28014-46-2
CAS Name: Estradiol phosphate polymer
Additional Names: PEP
Trademarks: Estradurin (Kabi)
Literature References: Polymeric ester of phosphoric acid and estradiol. Mol wt ~26,000. Prepn: Diczfalusy, Endocrinology 54, 471 (1954); Fernö et al., Acta Chem. Scand. 12, 1675 (1958); Diczfalusy et al., US 2928849 (1960 to AB Leo). Clinical pharmacology: P. O. Gunnarsson, B. J. Norlén, Prostate 13, 299 (1988). Clinical trial in prostatic carcinoma: J. Aro, ibid. 18, 131 (1991).
Properties: Solid, mp 195-202°. Very sol in aq pyridine; sol in aq alkali; very slightly sol in ethanol, ethanol + water (1:1), water, dioxane, acetone, chloroform. Intrinsic viscosity [h] in 0.25M NaCl soln at pH 7.5 = 0.04.
Melting point: mp 195-202°
Therap-Cat: Antineoplastic (hormonal).
Keywords: Antineoplastic (Hormonal); Estrogens. |