Title: Pentisomide
CAS Registry Number: 78833-03-1
CAS Name: a-[2-[Bis(1-methylethyl)amino]ethyl]-a-(2-methylpropyl)-2-pyridineacetamide
Additional Names: 2-[2-(diisopropylamino)ethyl]-4-methyl-2-(2-pyridyl)pentanamide; propisomide; penticainide
Manufacturers' Codes: CM-7857; ME-3202
Molecular Formula: C19H33N3O
Molecular Weight: 319.48
Percent Composition: C 71.43%, H 10.41%, N 13.15%, O 5.01%
Literature References: Sodium channel blocker; derivative of disopyramide, q.v. Prepn: H. Demarne et al., EP 27412; eidem, US 4356177 (1981, 1982 both to C. M. Industries); C. A. Bernhart et al., J. Med. Chem. 26, 451 (1983). Electrophysiological study: V. Kühlkamp et al., Int. J. Cardiol. 36, 69 (1992). HPLC determn in plasma, urine, and tissues: T. A. Plomp, M. J. H. Buijs, J. Chromatogr. 612, 123 (1993). Clinical evaluation: S. G. Priori et al., Am. J. Cardiol. 60, 1068 (1987); S. G. Mangini et al., Eur. Heart J. 12, 712 (1991). Review: S. Yuan, S. B. Olsson, Cardiovasc. Drug Rev. 11, 74-93 (1993).
Properties: White crystals from diisopropyl ether, mp 108-109°. Sol in water.
Melting point: mp 108-109°
Therap-Cat: Antiarrhythmic (class I).
Keywords: Antiarrhythmic. |