Title: PSK® (Kureha)
CAS Registry Number: 66455-27-4
Trademarks: KRESTIN (Kureha)
Literature References: Protein-bound polysaccharide; biological response modifier having immunostimulant and anticancer properties. Isolated from a basidiomycete, Coriolus versicolor (Fr.) Quel.: S. Otsuka et al., JP 73 8489 (1973 to Kureha), C.A. 80, 41025g (1974). Antitumor activity: S. Tsukagoshi et al., Prog. Chemother. (Antibacterial, Antiviral, Antineoplast.), Proc. Int. Congr. Chemother., 8th, Athens 1973 vol. 3, G. K. Daikos, Ed. (Hellen. Soc. Chemother., Athens, 1974) pp 799-803. Clinical studies as postoperative immunotherapy: M. Torisu et al., Cancer Immunol. Immunother. 31, 261 (1990); Y. Kuroda et al., Int. J. Clin. Oncol. 3, 311 (1998). Review: S. Tsukagoshi et al., Cancer Treat. Rev. 11, 131-155 (1984). Review of antimicrobial and biological activity: H. Sakagami, M. Takeda in Mushroom Biology and Mushroom Products (Chinese Univ. Press, Hong Kong, 1993) p 237-245; antimetastatic effects: H. Kobayashi et al., Cancer Epidemiol. Biomarkers Prev. 4, 275-281 (1995).
Properties: Brownish powder. Tasteless, but has a slight odor. Sol in water. Practically insol in methanol, pyridine, chloroform, benzene, hexane. pH of 1% soln is 6.6-7.2.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Immunomodulators. |