Title: N-Nitrosopyrrolidine
CAS Registry Number: 930-55-2
CAS Name: 1-Nitrosopyrrolidine
Additional Names: NPYR; NO-PYR
Molecular Formula: C4H8N2O
Molecular Weight: 100.12
Percent Composition: C 47.99%, H 8.05%, N 27.98%, O 15.98%
Literature References: Cyclic nitrosamine that occurs in food products and tobacco smoke. Prepn: F. C. Peterson, Ber. 21, 290 (1888). Carcinogenicity studies: H. Druckrey et al., Z. Krebsforsch. 69, 103 (1967); M. Greenblatt et al., J. Natl. Cancer Inst. 48, 1687 (1972); IARC Monographs 17, 313 (1978). Mechanism of mutagenicity: L. I. Hecker et al., Mutat. Res. 62, 213 (1979). Metabolism: R. C. Cottrell et al., Adv. Exp. Med. Biol. 136B, 1165 (1982).
Properties: Yellow liquid, bp20 104-106°. Sol in water. LD50 orally in rats: 900 mg/kg (Druckrey).
Boiling point: bp20 104-106°
Toxicity data: LD50 orally in rats: 900 mg/kg (Druckrey)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-207. |