Title: Morazone
CAS Registry Number: 6536-18-1
CAS Name: 1,2-Dihydro-1,5-dimethyl-4-[(3-methyl-2-phenyl-4-morpholinyl)methyl]-2-phenyl-3H-pyrazol-3-one
Additional Names: 4-[(3-methyl-2-phenylmorpholino)methyl]antipyrine; 1-phenyl-2,3-dimethyl-4-(2¢-phenyl-3¢-methylmorpholinomethyl)-5-pyrazolone
Manufacturers' Codes: R-445
Trademarks: Tarugan (Ravensberg)
Molecular Formula: C23H27N3O2
Molecular Weight: 377.48
Percent Composition: C 73.18%, H 7.21%, N 11.13%, O 8.48%
Literature References: Prepn: Hengen et al., Arzneim.-Forsch. 8, 421 (1958); Siemer, Doppstadt, US 2943022; US 3005818 (1960, 1961 both to Ravensberg Chem.). Metabolism: Cartoni et al., J. Chromatogr. 84, 419 (1973).
Properties: Crystals, mp 149-150°. Freely sol in chloroform; sol in methanol, acetone; slightly sol in ether.
Melting point: mp 149-150°
Derivative Type: Hydrochloride
CAS Registry Number: 50321-35-2
Molecular Formula: C23H27N3O2.HCl
Molecular Weight: 413.94
Percent Composition: C 66.74%, H 6.82%, N 10.15%, O 7.73%, Cl 8.56%
Properties: Crystals from methanol + acetone, mp 171-172° (dec). Sol in water.
Melting point: mp 171-172° (dec)
Therap-Cat: Analgesic; anti-inflammatory; antipyretic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazolones; Antipyretic. |