Title: Medullipin
CAS Registry Number: 97621-73-3
CAS Name: Medullipin I
Additional Names: antihypertensive neutral renomedullary lipid; ANRL
Literature References: Antihypertensive lipid prohormone produced by the renomedullary interstitial cells of the renal papilla under the control of the renal artery perfusion pressure. Converted to the active form, medullipin II, by the cytochrome P-450 dependent enzyme system of the liver. Medullipin II acts as as vasodilator that suppresses sympathetic activity, causes diuresis-natriuresis, and has a suppressive action on the CNS. Constitutes a feedback control of the renin-angiotensin system. Extraction from renomedullary interstitial cells: E. E. Muirhead et al., Lab. Invest. 35, 162 (1977); from renal venous effluent: E. E. Muirhead et al., J. Lab. Clin. Med. 99, 64 (1982). Biological activity: E. E. Muirhead et al., Hypertension 5, Suppl I, I-112 (1983); G. Karlström et al., Acta Physiol. Scand. 137, 521 (1989). Activation by the liver: E. E. Muirhead et al., Trans. Assoc. Am. Physicians 101, 226 (1988). Effect in spontaneously hypertensive rats: E. E. Muirhead et al., Hypertension 17, 1092 (1991). Review of medullipin system of blood pressure control: E. E. Muirhead, Am. J. Hypertens. 4, 556S-568S (1991). |