Title: Fomocaine
CAS Registry Number: 17692-39-6
CAS Name: 4-[3-[4-(Phenoxymethyl)phenyl]propyl]morpholine
Additional Names: 4-[3-(a-phenoxy-p-tolyl)propyl]morpholine
Manufacturers' Codes: P-652
Trademarks: Erbocain (Heilit)
Molecular Formula: C20H25NO2
Molecular Weight: 311.42
Percent Composition: C 77.14%, H 8.09%, N 4.50%, O 10.28%
Literature References: Prepn: GB 786128 (1957 to Promonta), C.A. 52, 9225h (1958); H. Oelschläger, Arzneim.-Forsch. 9, 313 (1959). Improved synthesis: eidem, ibid. 27, 1625 (1977). Pharmacology: O. Nieschulz et al., ibid. 8, 539 (1958). Metabolism: H. Blume, H. Oelschläger, ibid. 28, 956 (1978). Bioavailability and local anesthetic effect: H. Oelschläger, D. Rothley, ibid. 29, 693 (1979).
Properties: Colorless crystals from petr ether, mp 52-53°. bp1.1 238-240°. uv max (ethanol): 220, 269 nm (e 15820, 1373). LD50 i.v. in mice: 175 mg/kg (Nieschulz).
Melting point: mp 52-53°
Boiling point: bp1.1 238-240°
Absorption maximum: uv max (ethanol): 220, 269 nm (e 15820, 1373)
Toxicity data: LD50 i.v. in mice: 175 mg/kg (Nieschulz)
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local). |