Title: Fluspirilene
CAS Registry Number: 1841-19-6
CAS Name: 8-[4,4-Bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Manufacturers' Codes: R-6128
Trademarks: Imap (McNeil); Redeptin (SK & F)
Molecular Formula: C29H31F2N3O
Molecular Weight: 475.57
Percent Composition: C 73.24%, H 6.57%, F 7.99%, N 8.84%, O 3.36%
Literature References: Prepn: BE 633914; P. A. J. Janssen, US 3238216 (1963, 1966 both to Janssen). HPLC determn: A. H. Hikal, H. I. Al-Shoura, J. Liq. Chromatogr. 5, 2205 (1982). Metabolism in rat: J. P. P. Heykants, Life Sci. 8, Part I, 1029 (1969). Pharmacology: P. A. J. Janssen et al., Arzneim.-Forsch. 20, 1689 (1970). Calcium channel blocking activity: R. J. Gould et al., Proc. Natl. Acad. Sci. USA 80, 5122 (1983); J. P. Galizzi et al., ibid. 83, 7513 (1986). Clinical trials in schizophrenia: H. Immich et al., Arzneim.-Forsch. 20, 1699 (1970); G. Chouinard et al., J. Clin. Psychopharmacol. 6, 21 (1986).
Properties: White to yellowish amorphous or crystalline solid, mp 187.5-190°. Soly in water: 0.015-0.020 mg/ml. LD50 i.m. in rats: 146 ±14 mg/kg (Janssen).
Melting point: mp 187.5-190°
Toxicity data: LD50 i.m. in rats: 146 ±14 mg/kg (Janssen)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic. |