Title: Fenpentadiol
CAS Registry Number: 15687-18-0
CAS Name: 2-(4-Chlorophenyl)-4-methyl-2,4-pentanediol
Additional Names: 2-methyl-4-(p-chlorophenyl)-2,4-pentanediol
Manufacturers' Codes: RD-292
Trademarks: Tredum (Hatrol)
Molecular Formula: C12H17ClO2
Molecular Weight: 228.72
Percent Composition: C 63.02%, H 7.49%, Cl 15.50%, O 13.99%
Literature References: Prepn: Valette, FR M1984 (1963 to Labs Albert Rolland), C.A. 60, 2828h (1964). Psychopharmacology: J. Ginet et al., Arzneim.-Forsch. 21, 1 (1971). Pharmacokinetics: Y. Dormand, J. C. Levron, Eur. J. Toxicol. 5, 43 (1972). Clinical evaluations: P. Mouren et al., Marseille Med. 106, 555 (1969); P. J. Parquet, Lille Med. 18, 836 (1973). Toxicity: H. Kriegel et al., Arzneim.-Forsch. 21, 9 (1971).
Properties: Crystals from petr ether, mp 76.5°. uv max (0.1% in abs ethanol): 228 nm. LD50 in male, female mice, rats (mg/kg): 940, 995, 1200, 1250 orally (Kriegel).
Melting point: mp 76.5°
Absorption maximum: uv max (0.1% in abs ethanol): 228 nm
Toxicity data: LD50 in male, female mice, rats (mg/kg): 940, 995, 1200, 1250 orally (Kriegel)
Therap-Cat: Antidepressant.
Keywords: Antidepressant.
Status: This monograph has been retired and is no longer subject to revision or update. |