Title: Exametazime
CAS Registry Number: 105613-48-7
CAS Name: (2E,2¢E,3R,3¢R)-rel-3,3¢-[(2,2-Dimethyl-1,3-propanediyl)diimino]bis-2-butanone dioxime
Additional Names: (RR,SS)-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime; (±)-(3RS,3¢RS)-3,3¢-[(2,2-dimethyltrimethylene)diimino]di-2-butanone dioxime; d,l-hexamethylpropyleneamine oxime; d,l-HM-PAO; hexametazine
Trademarks: Ceretec (Amersham)
Molecular Formula: C13H28N4O2
Molecular Weight: 272.39
Percent Composition: C 57.32%, H 10.36%, N 20.57%, O 11.75%
Literature References: Propyleneamine oxime derivative that forms a neutral, lipophilic complex with 99mTc which diffuses across cellular membranes, including the blood brain barrier. Used in regional cerebral blood flow imaging. Prepn: L. R. Canning et al., EP 194843; eidem, US 4789736 (1986, 1988 both to Amersham). Prepn and ra-diopharmacology of 99mTc complex: D. P. Nowotnik et al., Nucl. Med. Commun. 6, 499 (1985); R. D. Neirinckx et al., J. Nucl. Med. 28, 191 (1987). Clinical comparison of isomers: P. F. Sharp et al., ibid. 27, 171 (1986). Biodistribution in humans: K. Nakamura et al., Eur. J. Nucl. Med. 15, 100 (1989). Clinical evaluation in single photon emission tomography (SPECT) of meningiomas: S. Nakano et al., J. Nucl. Med. 30, 1101 (1989). 99mTc radiolabeling of human platelets: H. J. Danpure, S. Osman, Nucl. Med. Commun. 9, 267 (1988); of human leukocytes: H. J. Danpure et al., ibid. 465. Clinical study of labeled leukocytes for imaging inflammatory lesions: J. H. Reynolds, Clin. Radiol. 42, 195 (1990). Series of articles on basic and clinical studies: J. Cereb. Blood Flow Metab. 8, S1-S126 (1988).
Properties: Crystals from ethyl acetate, mp 128-130°.
Melting point: mp 128-130°
Therap-Cat: 99mTc complex as diagnostic aid (radioactive imaging agent). |