Title: Erythrosine
CAS Registry Number: 16423-68-0
CAS Name: 3¢,6¢-Dihydroxy-2¢,4¢,5¢,7¢-tetraiodospiro[isobenzofuran-1(3H),9¢-[9H]xanthen]-3-one disodium salt
Additional Names: 2¢,4¢,5¢,7¢-tetraiodofluorescein disodium salt; erythrosine BS; erythrosine B; FD & C Red No. 3; C.I. Food Red 14; C.I. Acid Red 51; C.I. 45430
Molecular Formula: C20H6I4Na2O5
Molecular Weight: 879.86
Percent Composition: C 27.30%, H 0.69%, I 57.69%, Na 5.23%, O 9.09%
Literature References: Prepn: Gilliard et al., DE 108838 (1899); Frdl. 5, 215; Gomberg, Tabern, J. Ind. Eng. Chem. 14, 1115 (1922); Dolinsky, Jones, J. Assoc. Off. Agric. Chem. 34, 114 (1951); Colour Index vol. 4 (3rd ed., 1971) p 4428. Structure: Holmes, Scanlan, J. Am. Chem. Soc. 49, 1594 (1927). HPLC determn: F. E. Lancaster, J. F. Lawrence, J. Chromatogr. 388, 248 (1987). Acute toxicity: K. R. Butterworth et al., Food Cosmet. Toxicol. 14, 525 (1976); S. L. Yankell et al., J. Periodontol. 48, 228 (1977). Carcinogenicity studies in rodents: J. F. Borzelleca et al., Food Chem. Toxicol. 25, 723, 735 (1987).
Properties: Brown powder. Absorption max (water): 524 nm; in 95% alcohol: 531 nm. Soluble in water to cherry-red soln; sol in alcohol. HCl added to an aq soln produces a yellowish-brown ppt. Sodium hydroxide produces a red ppt sol in an excess of the reagent. LD50 in male, female mice, male, female rats (g/kg): 0.40, 0.32, 0.34, 0.37 i.p.; 6.7, 6.9, 7.4, 6.8 orally (Butterworth). Also reported as LD50 in mice, rats (mg/kg): 2558, 2891 orally (Yankell).
Absorption maximum: Absorption max (water): 524 nm; in 95% alcohol: 531 nm
Toxicity data: LD50 in male, female mice, male, female rats (g/kg): 0.40, 0.32, 0.34, 0.37 i.p.; 6.7, 6.9, 7.4, 6.8 orally (Butterworth); LD50 in mice, rats (mg/kg): 2558, 2891 orally (Yankell)
NOTE: Consult latest governmental regulations on use in food, drugs and cosmetics.
Use: Biological stain; color additive. |