Title: Emodepside
CAS Registry Number: 155030-63-0
CAS Name: Cyclo[(aR)-a-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(aR)-a-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]
Manufacturers' Codes: Bay-44-4400; PF-1022-221
Molecular Formula: C60H90N6O14
Molecular Weight: 1119.39
Percent Composition: C 64.38%, H 8.10%, N 7.51%, O 20.01%
Literature References: Cyclic octadepsipeptide that binds to presynaptic latrophilin receptors in nematodes. Semisynthetic derivative of PF1022A, a fungal metabolite of Mycelia sterilia. Prepn: H. Nishiyama et al., WO 9319053; eidem, US 5514773 (1993, 1996 both to Fujisawa). In vivo anthelmintic activity: A Harder, G. von Samson-Himmelstjerna, Parasitol. Res. 87, 924 (2001); H. Zahner et al., Int. J. Parasitol. 31, 1515 (2001). Review of mechanism of action studies: A. Harder et al., Parasitol. Res. S1-S10 (2005).
Properties: White to yellowish powder. Soly in water: 8.1 mg/l (pH 4); 5.2 mg/l (pH 7), 6.1 mg/l (pH 10). Log P (octanol/water): 4.9 (pH 7).
Log P: Log P (octanol/water): 4.9 (pH 7)
Derivative Type: Combination with praziquantel
Trademarks: Profender (Bayer)
Literature References: Series of articles on therapeutic use in cats, reptiles and rodents: Parasitol. Res. 97, S33-S69 (2005).
Therap-Cat-Vet: Anthelmintic (Nematodes and Cestodes). |