Title: Drofenine
CAS Registry Number: 1679-76-1
CAS Name: a-Cyclohexylbenzeneacetic acid 2-(diethylamino)ethyl ester
Additional Names: a-phenylcyclohexaneacetic acid 2-(diethylamino)ethyl ester; 2-diethylaminoethyl a-phenylcyclohexaneacetate; hexahydroadiphenine
Molecular Formula: C20H31NO2
Molecular Weight: 317.47
Percent Composition: C 75.67%, H 9.84%, N 4.41%, O 10.08%
Literature References: Prepn: Miescher, Hoffman, US 2265184; US 2265185 (both 1941 to Ciba). Pharmacology and toxicity: Fleisch et al., Arzneim.-Forsch. 11, 1119 (1961).
Properties: bp0.15 158°.
Boiling point: bp0.15 158°
Derivative Type: Hydrochloride
CAS Registry Number: 548-66-3
Molecular Formula: C20H31NO2.HCl
Molecular Weight: 353.93
Percent Composition: C 67.87%, H 9.11%, N 3.96%, O 9.04%, Cl 10.02%
Properties: Crystals from alc + petr ether, mp 145-147°. Freely sol in water; very sparingly sol in alc, ether. A 5% aq soln is neutral to litmus. LD50 i.v. in mice: 65.6 mg/kg (Fleisch).
Melting point: mp 145-147°
Toxicity data: LD50 i.v. in mice: 65.6 mg/kg (Fleisch)
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic. |