Title: Disufenton
CAS Registry Number: 168021-77-0
CAS Name: 4-[[(1,1-Dimethylethyl)oxidoimino]methyl]-1,3-benzenedisulfonic acid
Additional Names: 2,4-disulfonyl-a-phenyl-tert-butylnitrone
Molecular Formula: C11H15NO7S2
Molecular Weight: 337.37
Percent Composition: C 39.16%, H 4.48%, N 4.15%, O 33.20%, S 19.01%
Literature References: Nitrone-based spin trapping agent; derivative of PBN, q.v. Prepn: J. M. Carney, WO 9517876; idem, US 5488145 (1995, 1996 both to Oklahoma Med. Res. Found.). Pharmacology: S. Kuroda et al., J. Cereb. Blood Flow Metab. 19, 778 (1999). Comparative radical trapping study: K. R. Maples et al., Free Radical Res. 34, 417 (2001). Clinical pharmacokinetics: K. R. Lees et al., Stroke 32, 675 (2001). Clinical trial in acute ischemic stroke: idem et al., N. Engl. J. Med. 354, 588 (2006). Reviews of pharmacology and therapeutic potential: P. A. Lapchak, Curr. Opin. Invest. Drugs 3, 1758-1762 (2002); P. A. Lapchak, D. M. Araujo, CNS Drug Rev. 9, 253-262 (2003).
Properties: White powder. Soly (g/ml): water >1.
Derivative Type: Sodium salt
CAS Registry Number: 168021-79-2
Additional Names: Disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide
Manufacturers' Codes: ARL-16556; CPI-22; CXY-059; NXY-059
Trademarks: Cerovive (AstraZeneca)
Molecular Formula: C11H13NNa2O7S2
Molecular Weight: 381.33
Percent Composition: C 34.65%, H 3.44%, N 3.67%, Na 12.06%, O 29.37%, S 16.82%
Therap-Cat: Neuroprotective.
Keywords: Neuroprotective. |