Title: Diphemanil Methylsulfate
CAS Registry Number: 62-97-5
CAS Name: 4-(Diphenylmethylene)-1,1-dimethylpiperidinium methyl sulfate
Additional Names: p-(a-phenylbenzylidene)-1,1-dimethylpiperidinium methylsulfate; N,N-dimethyl-4-piperidylidene-1,1-diphenylmethane methylsulfate
Trademarks: Prantal (Schering)
Molecular Formula: C21H27NO4S
Molecular Weight: 389.51
Percent Composition: C 64.75%, H 6.99%, N 3.60%, O 16.43%, S 8.23%
Literature References: Anticholinergic. Prepn: N. Sperber et al., J. Am. Chem. Soc. 73, 5010 (1951); N. Sperber et al., US 2739968 (1956 to Schering). Pharmacological properties and toxicity data: S. Margolin et al., Proc. Soc. Exp. Biol. Med. 78, 576 (1951). Clinical evaluation in treatment of gustatory sweating: O. Laccourreye et al., Laryngoscope 100, 1651 (1990). Clinical pharmacokinetics: A. M. Vidal et al., Eur. J. Clin. Pharmacol. 42, 689 (1992).
Properties: Crystals, mp 194-195°. Soluble in water. LD50 in rats, mice, guinea pigs (mg/kg): 1107, 64, 404 orally (Margolin).
Melting point: mp 194-195°
Toxicity data: LD50 in rats, mice, guinea pigs (mg/kg): 1107, 64, 404 orally (Margolin)
Therap-Cat: In treatment of hyperhidrosis.
Keywords: Antimuscarinic. |