Diamine Oxidase

Literature References: Copper containing enzyme present in various tissues, esp in the intestinal mucosa; catalyzes the oxidative deamination of histamine and other biogenic amines to form the corresponding aldehydes, ammonia and hydrogen peroxide. Rate-limiting enzyme in the terminal catabolism of polyamines that are essential for cell proliferation. Discovery of a histamine-inactivating enzyme in lung tissue: C. H. Best, J. Physiol. 67, 256 (1929). Identification of activity on other diamines: E. A. Zeller, Helv. Chim. Acta 21, 880 (1938). Extraction from hog kidneys: B. Swedin, Acta Med. Scand. 114, 21 (1943). Improved purification: D. Wilflingseder, H. G. Schwelberger, J. Chromatogr. B 737, 161 (2000). HPLC determn in plasma: P. A. Biondi et al., J. Chromatogr. 507, 333 (1990). Reviews: F. Buffoni, Pharmacol. Rev. 18, 1163-1199 (1966); M. C. J. Wolvekamp, R. W. F. de Bruin, Dig. Dis. 12, 2-14 (1994). Review of role in polyamine metabolism: A. Sessa, A. Perin, Agents Actions 43, 69-77 (1994); of role in cell growth and differentiation: P. Pietrangeli, B. Mondovi, Neurotoxicology 25, 317-324 (2004).