Defibrotide

Literature References: Sodium salt of polydeoxyribonucleotide extract from mammalian lung which stimulates fibrinolysis. mol wt 45,000-50,000 daltons. Prepn: A. Butti et al., DE 2154278; eidem, US 3899481 (1972, 1975 both to Crinos). Antithrombotic activity: R. Niada et al., Thromb. Res. 23, 233 (1981). Pharmacokinetics and profibrinolytic activity in rabbits: R. Pescador et al., ibid. 30, 1 (1983). Clinical trial as antithrombotic: S. Coccheri et al., Int. J. Clin. Pharmacol. Res. 2, 227 (1982). Clinical evaluation in thrombotic microangiopathy: V. Bonomini et al., Nephron 40, 195 (1985). Symposium on pharmacology and clinical efficacy: O. N. Ulutin, Ed., Haemostasis 16, Suppl. 1, 1-68 (1986). Review of pharmacology and therapeutic use: K. J. Palmer, K. L. Goa, Drugs 45, 259-294 (1993).